Journal Club
2025
Oct 10 2025
Presenter: Beirui Niu
Paper: Zhou Zhu et al., Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean.
Cell, 2025.
doi: 10.1126/science.adl2356
Sep 19 2025
Presenter: Zelin Niu
Paper: Oliver Lemke et al., The role of metabolism in shaping enzyme structures over 400 million years.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-09205-6
Sep 12 2025
Presenter: Liping Jiang
Paper: Martin Sikora et al., The spatiotemporal distribution of human pathogens in ancient Eurasia.
Nature Genetics, 2025.
doi: https://doi.org/10.1038/s41586-025-09192-8
Sep 5 2025
Presenter: Jinhong Chen
Paper: Anna A. Igolkina et al., A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism.
Nature Genetics, 2025.
doi: https://doi.org/10.1038/s41588-025-02293-0
Aug 22 2025
Presenter: Yuting Li
Paper: Julia Engelhorn et al., Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize.
Nature Genetics, 2025.
doi: https://doi.org/10.1038/s41588-025-02246-7
Aug 15 2025
Presenter: Xuebing Qiu
Paper: Sophia G. Zebell et al., Cryptic variation fuels plant phenotypic change through hierarchical epistasis.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-09243-0
Aug 7 2025
Presenter: Shuyi Xing
Paper: Zhiyang Zhang et al., Ancient hybridization underlies tuberization and radiation of the potato lineage.
Nature Ecology & Evolution, 2025.
doi: 10.1016/j.cell.2025.06.034
Aug 1 2025
Presenter: Jiayu Dong
Paper: Stepfanie M. Aguillon et al., Pervasive gene flow despite strong and varied reproductive barriers in swordtails.
Nature Ecology & Evolution, 2025.
doi: https://doi.org/10.1038/s41559-025-02669-9
Jul 11 2025
Presenter: Jijin Zhang
Paper: Alexandre P. Marand et al., The genetic architecture of cell type–specific cis regulation in maize.
Science, 2025.
doi: 10.1126/science.ads6601
Jun 11 2025
Presenter: Song Xu
Paper: Liyang Song et al., Systems-level design principles of metabolic rewiring in an animal.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-08757-x
May 30 2025
Presenter: Xinyue Song
Paper: Xuhang Li et al., Systems-level design principles of metabolic rewiring in an animal.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-08636-5
Apr 18 2025
Presenter: Da Zheng
Paper: Sile Hu et al., Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits.
Nature Genetics, 2025.
doi: https://doi.org/10.1038/s41588-024-02035-8
Apr 11 2025
Presenter: Ao Li
Paper: Michael C. Grundler et al., A geographic history of human genetic ancestry.
Science, 2025.
doi: 10.1126/science.adp464
Mar 28 2025
Presenter: Jingchen Yuan
Paper: David A. Duchêne et al., Drivers of avian genomic change revealed by evolutionary rate decomposition.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-08777-7
Mar 21 2025
Presenter: Yaqin Hu
Paper: Matthias Benoit et al., Solanumpan-genetics reveals paralogues as contingencies in crop engineering.
Nature, 2025.
doi: https://doi.org/10.1038/s41586-025-08619-6
Mar 18 2025
Presenter: You Qing
Paper: Sudarshan Pinglay et al., Multiplex generation and single-cell analysis of structural variants in mammalian genomes.
Science, 2025.
doi: 10.1126/science.ado5978
Mar 6 2025
Presenter: Jun Xu
Paper: Hongbo Liu et al., Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.
Science, 2025.
doi: 10.1126/science.adp4753
Feb 28 2025
Presenter: Beijing Zhu
Paper: Chloé Beaulieu et al., The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment.
Nature Genetics, 2025.
doi: https://doi.org/10.1038/s41588-024-02071-4
Feb 21 2025
Presenter: Beirui Niu
Paper: Jing-Jing Xu et al., Design of CoQ10 crops based on evolutionary history.
Cell, 2025.
doi: https://doi.org/10.1016/j.cell.2025.01.023
Feb 14 2025
Presenter: Zelin Niu
Paper: Lin Cheng et al., Leveraging a phased pangenome for haplotype design of hybrid potato.
Science, 2025.
doi: https://doi.org/10.1038/s41586-024-08476-9
Feb 7 2025
Presenter: Xuebing Qiu
Paper: Thomas Hayes et al., Simulating 500 million years of evolution with a language model.
Science, 2025.
doi: 10.1126/science.ads0018
Jan 6 2025
Presenter: Jiayu Dong
Paper: Leonardo N. M. Iasi et al., Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans.
Science, 2024.
doi: 10.1126/science.adq3010
2024
Dec 20 2024
Presenter: Jijin Zhang
Paper: Junli Liu et al., The complete telomere-to-telomere sequence of a mouse genome.
Science, 2024.
doi: 10.1126/science.adq8191
Dec 6 2024
Presenter: Song Xu
Paper: Barrio-Hernandez, I. et al., Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics, 2023.
doi: https://doi.org/10.1038/s41588-023-01327-9
Dec 6 2024
Presenter: Xinyue Song
Paper: Jiao, C et al., Pan-genome bridges wheat structural variations with habitat and breeding.
Nature, 2024.
doi: https://doi.org/10.1038/s41586-024-08277-0
Nov 29 2024
Presenter: Da Zheng
Paper: Eric Nguyen et al., Sequence modeling and design from molecular to genome scale with Evo.
Science, 2024.
doi: 10.1126/science.ado9336
Nov 22 2024
Presenter: Jingchen Yuan
Paper: Cheng, S et al., Harnessing landrace diversity empowers wheat breeding.
Nature, 2024.
doi: 10.1126/sciadv.aav9963
Nov 15 2024
Presenter: Ao Li
Paper: Hernán E. Morales et al., Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast.
Science, 2024.
doi: 10.1126/sciadv.aav9963
Nov 8 2024
Presenter: You Qing
Paper: Wanqiu Ding et al., Adaptive functions of structural variants in human brain development.
Science, 2024.
doi: 10.1126/sciadv.adl4600
Nov 1 2024
Presenter: Jun Xu
Paper: James W. Satterlee et al., Convergent evolution of desiccation tolerance in grasses.
Science, 2024.
doi: 10.1126/science.ado1663
Sep 20 2024
Presenter: Yaqin Hu
Paper: Marks, R.A. et al., Convergent evolution of desiccation tolerance in grasses.
Nature Plant, 2024.
doi: https://doi.org/10.1038/s41477-024-01729-5
Sep 6 2024
Presenter: Bingjie Zhu
Paper: Tao Shi et al., Position-dependent function of human sequence-specific transcription factors.
The Plant Cell, 2024.
doi: https://doi.org/10.1093/plcell/koae227
Aug 29 2024
Presenter: Beirui Niu
Paper: Duttke, S.H. et al., Position-dependent function of human sequence-specific transcription factors.
Nature, 2024.
doi: https://doi.org/10.1038/s41586-024-07662-z
Aug 23 2024
Presenter: Xuebing Qiu
Paper: Berube, B. et al., Teosinte Pollen Drive guides maize diversification and domestication by RNAi.
Nature, 2024.
doi: https://doi.org/10.1038/s41586-024-07788-0
Aug 9 2024
Presenter: Jiayu Dong
Paper: Liming Li et al., Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years.
Science, 2024.
doi: 10.1126/science.adi1768
Aug 1 2024
Presenter: Ao Li
Paper: Xin Wei et al., Natural selection drives emergent genetic homogeneity in a century-scale experiment with barley.
Science, 2024.
doi: 10.1126/science.adm8762
Jul 19 2024
Presenter: Liping Jiang
Paper: Jacob B. Landis et al., Natural selection drives emergent genetic homogeneity in a century-scale experiment with barley.
Science, 2024.
doi: 10.1126/science.adl0038
Jul 12 2024
Presenter: Jijin Zhang
Paper: Cindy Wen et al., Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain.
Science, 2024.
doi: 10.1126/science.adh0829
Apr 19 2024
Presenter: Song Xu
Paper: Mostafavi, H. et al., Systematic differences in discovery of genetic effects on gene expression and complex traits.
Nature Genetics, 2023.
doi: https://doi.org/10.1038/s41588-023-01529-1
Apr 12 2024
Presenter: Yafei Guo
Paper: Yeaman Samuel, Whiting, James. et al., Core genes driving climate adaptation in plants.
2023.
doi: 10.21203/rs.3.rs-3434061/v1.
Mar 29 2024
Presenter: Xinyue Song
Paper: Matteo Rossi. et al., Adaptive introgression of a visual preference gene.
Science, 2024, 383,1368-1373.
doi: 10.1126/science.adj9201.
Mar 22 2024
Presenter: Lipeng Kang
Paper: Peng-Fei Ma, Yun-Long Liu, Cen Guo. et al., Genome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance.
Nature Genetics, 2024.
doi: https://doi.org/10.1038/s41588-024-01683-0.
Mar 14 2024
Presenter: Zhiliang Zhang
Paper: Van de Weyer, A.-L., Monteiro, F., Furzer, O.J. et al., A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana.
Cell, 2019, 178, 1260-1272.
doi: 10.1016/j.cell.2019.07.038.
Mar 08 2024
Presenter: Da Zheng
Paper: Alejandro Couce. et al., Changing fitness effects of mutations through long-term bacterial evolution.
Science, 2024, 383,eadd1417.
doi: 10.1126/science.add1417
Mar 01 2024
Presenter: Yaqin Hu
Paper: Pascal O. Title. et al., The macroevolutionary singularity of snakes.
Science, 2024, 383,918-923.
doi: 10.1126/science.adh2449
Feb 23 2024
Presenter: You Qing
Paper: Yu Xu, Scott C. Ritchie, Yujian Liang. et al., An atlas of genetic scores to predict multi-omic traits.
Nature, 2023, 616, 123–131.
doi: https://doi.org/10.1038/s41586-023-05844-9
Jan 25 2024
Presenter: Jun Xu
Paper: Jinyan Teng, Yahui Gao, Hongwei Yin. et al., A compendium of genetic regulatory effects across pig tissues.
Nature Genetics, 2024, 56, 112–123.
doi: https://doi.org/10.1038/s41588-023-01585-7
Jan 12 2024
Presenter: Bingjie Zhu
Paper: Franziska Saul, Mathias Scharmann, Takanori Wakatake. et al., Subgenome dominance shapes novel gene evolution in the decaploid pitcher plant Nepenthes gracilis.
Nature Plants, 2023, 9, 2000–2015.
doi: https://doi.org/10.1038/s41477-023-01562-2
2023
Dec 22 2023
Presenter: Beirui Niu
Paper: Songpeng Zu, Yang Eric Li, Kangli Wang. et al., Single-cell analysis of chromatin accessibility in the adult mouse brain.
Nature, 2023, 624, 378–389.
doi: https://doi.org/10.1038/s41586-023-06824-9
Dec 15 2023
Presenter: Zelin Niu
Paper: Xiaozhong Wang, Zhengxia Dou, Shi Feng. et al., Global food nutrients analysis reveals alarming gaps and daunting challenges.
Nat Food, 2023, 4, 1007–1017.
doi: https://doi.org/10.1038/s43016-023-00851-5
Dec 08 2023
Presenter: Xuebing Qiu
Paper: Barley AJ, Nieto-Montes de Oca A, Manríquez-Morán NL, Thomson RC. The evolutionary network of whiptail lizards reveals predictable outcomes of hybridization.
Science, 2022, 377(6607):773-777.
doi: 10.1126/science.abn1593
Dec 01 2023
Presenter: Jiayu Dong
Paper: Meier JI, McGee MD, Marques DA, Mwaiko S, Kishe M, Wandera S, Neumann D, Mrosso H, Chapman LJ, Chapman CA, Kaufman L, Taabu-Munyaho A, Wagner CE, Bruggmann R, Excoffier L, Seehausen O. Cycles of fusion and fission enabled rapid parallel adaptive radiations in African cichlids.
Science, 2023, 29;381(6665):eade2833.
doi: 10.1126/science.ade28333
Nov 24 2023
Presenter: Jijin Zhang
Paper: Horton CA, Alexandari AM, Hayes MGB, Marklund E, Schaepe JM, Aditham AK, Shah N, Suzuki PH, Shrikumar A, Afek A, Greenleaf WJ, Gordân R, Zeitlinger J, Kundaje A, Fordyce PM. Short tandem repeats bind transcription factors to tune eukaryotic gene expression.
Science, 2023, 22;381(6664):eadd1250.
doi: 10.1126/science.add1250
Nov 17 2023
Presenter: Liping Jiang
Paper: Poppenwimer T, Mayrose I, DeMalach N. Revising the global biogeography of annual and perennial plants.
Nature, 2023, 624(7990):109-114.
doi: 10.1038/s41586-023-06644-x
Nov 10 2023
Presenter: Song Xu
Paper: Jiaqi You, Zhenping Liu, Zhengyang Qi. et al., Regulatory controls of duplicated gene expression during fiber development in allotetraploid cotton.
Nature Genetics, 2023, 55, 1987–1997
doi: https://doi.org/10.1038/s41588-023-01530-8
Oct 27 2023
Presenter: Yafei Guo
Paper: Bernatchez, L., Ferchaud, AL., Berger, C.S. et al., Genomics for monitoring and understanding species responses to global climate change.
Nature Reviews Genetics, 2023.
doi: https://doi.org/10.1038/s41576-023-00657-y
Oct 20 2023
Presenter: Xinyue Song
Paper: Shifeng Cheng, Cong Feng, Luzie U. Wingen. et al., Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience.
bioRxiv, 2023.
doi: https://doi.org/10.1101/2023.10.04.560903
Sep 22 2023
Presenter: Lipeng Kang
Paper: Patrick F. Sullivan et al.,, Leveraging base-pair mammalian constraint to understand genetic variation and human disease.
Science, 2023. 380,eabn2937.
doi: 10.1126/science.abn2937
Sep 15 2023
Presenter: Zhiliang Zhang
Paper: Sergey Aganezov et al.,, A complete reference genome improves analysis of human genetic variation.
Science, 2022, 376,eabl3533.
doi: 10.1126/science.abl3533
Aug 25 2023
Presenter: You Qing
Paper: Hong Wu et al.,, Hybrid origin of a primate, the gray snub-nosed monkey.
Science, 2022, 380,eabl4997.
doi: 10.1126/science.abl4997
Jul 21 2023
Presenter: Yaqin Hu
Paper: Matthew J. Christmas et al.,, Evolutionary constraint and innovation across hundreds of placental mammals.
Science, 2023, 380,eabn3943.
doi: 10.1126/science.abn3943
Jul 14 2023
Presenter: Jun Xu
Paper: John A. Morris et al.,, Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens.
Science, 2023, 380,eadh7699.
doi: 10.1126/science.adh7699
Apr 14 2023
Presenter: Bingjie Zhu
Paper: Novakovsky, G., Dexter, N., Libbrecht, M.W. et al., Obtaining genetics insights from deep learning via explainable artificial intelligence.
Nature Reviews Genetics, 2023, 24:125–137.
doi: https://doi.org/10.1038/s41576-022-00532-2
Apr 07 2023
Presenter: Beirui Niu
Paper: Yang Dong et al.,, Dual domestications and origin of traits in grapevine evolution.
Science, 2023, 379:892-901.
doi: 10.1126/science.add8655
Mar 24 2023
Presenter: Zelin Niu
Paper: Chenkun Yang, Shuangqian Shen, Shen Zhou, Yufei Li, Yuyuan Mao, Junjie Zhou, Yuheng Shi, Longxu An, Qianqian Zhou, Wenju Peng, Yuanyuan Lyu, Xuemei Liu, Wei Chen, Shouchuang Wang, Lianghuan Qu, Xianqing Liu, Alisdair R. Fernie, Jie Luo,
Rice metabolic regulatory network spanning the entire life cycle.
Molecular Plant, 2020, 15(2):258-275.
doi: https://doi.org/10.1016/j.molp.2021.10.005
Mar 03 2023
Presenter: Xuebing Qiu
Paper: Gualberto JM, Newton KJ. Plant Mitochondrial Genomes: Dynamics and Mechanisms of Mutation.
Annual Review of Plant Biology,2017, 68:225-252.
doi: 10.1146/annurev-arplant-043015-112232.
Feb 24 2023
Presenter: Hangyuan Cheng
Paper: Zhang, X. et al., Genomes of the Banyan Tree and Pollinator Wasp Provide Insights into Fig-Wasp Coevolution.
Cell.2020, 183, 875-889.e17.
doi: https://doi.org/10.1016/j.cell.2020.09.043
Feb 17 2023
Presenter: Hua Zhang
Paper: Kurki, M.I., Karjalainen, J., Palta, P. et al., FinnGen provides genetic insights from a well-phenotyped isolated population.
Nature, 2022, 613, 508–518.
doi: https://doi.org/10.1038/s41586-022-05473-8
Feb 10 2023
Presenter: Jiayu Dong
Paper: Tauras P. Vilgalys et al., ,
Selection against admixture and gene regulatory divergence in a long-term primate field study.
Science,2022, 377,635-641.
doi: 10.1126/science.abm4917
2022
Dec 30 2022
Presenter: Liping Jiang
Paper: Martin G, Hélène C, Antoine N. et al.,
Competition and coevolution drive the evolution and the diversification of CRISPR immunity. bioRxiv, 2022.
doi: https://doi.org/10.1101/2021.11.12.468349
Dec 23 2022
Presenter: Jijin Zhang
Paper: Ebler, J., Ebert, P., Clarke, W.E. et al.,
Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes. Nature Genetics, 2022, 54:518–525.
doi: https://doi.org/10.1038/s41588-022-01043-w
Dec 16 2022
Presenter: Song Xu
Paper: Replogle JM, Saunders RA, Pogson AN, et al.,
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell, 2022, 185(14):2559-2575.
doi: https://doi.org/10.1016/j.cell.2022.05.013
Dec 09 2022
Presenter: Daxing Xu
Paper: Wohns, A. W. et al.,
A unified genealogy of modern and ancient genomes Science, 2022, 375(6583):8264.
doi: https://www.science.org/doi/10.1126/science.abi8264
Nov 25 2022
Presenter: Yafei Guo
Paper: Bosse M, Spurgin L, Laine V. et al.,
Recent natural selection causes adaptive evolution of an avian polygenic trait Science, 2017, 358(6361):365-368.
doi: https://www.science.org/doi/10.1126/science.aal3298
Nov 18 2022
Presenter: Xinyue Song
Paper: Yengo, L., Vedantam, S., Marouli, E. et al.,
A saturated map of common genetic variants associated with human height Nature, 2022, 610:704–712.
doi: https://doi.org/10.1038/s41586-022-05275-y
Nov 11 2022
Presenter: Lipeng Kang
Paper: Collins, R.L., Brand, H., Karczewski, K.J. et al.,
Origins and evolution of extreme life span in Pacific Ocean rockfishes Science, 2021, 374(6569):842-847.
doi: https://www.science.org/doi/full/10.1126/science.abg5332
Nov 04 2022
Presenter: Zhiliang Zhang
Paper: Collins, R.L., Brand, H., Karczewski, K.J. et al.,
A structural variation reference for medical and population genetics Nature, 2020, 581:444–451.
doi: https://doi.org/10.1038/s41586-020-2287-8
Oct, 28 2022
Presenter: Jun Xu
Paper: Lin Z, Liu Y, Liu S. et al.,
Nested epistasis enhancer networks for robust genome regulation Science, 2022, 377-(6610):1077-1085.
doi: https://www.science.org/doi/10.1126/science.abk3512
Sep 30, 2022
Presenter: Bingjie Zhu
Paper: Liu, S., Gao, Y., Canela-Xandri, O. et al.,
A multi-tissue atlas of regulatory variants in cattle Nature Genetics, 2022, 54:1438-1447.
doi: https://doi.org/10.1038/s41588-022-01153-5
Sep 23, 2022
Presenter: Beirui Niu
Paper: Wang, Z., Emmerich, A., Pillon, N.J. et al.,
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention Nature Genetics, 2022, 54:1332–1344.
doi: https://doi.org/10.1038/s41588-022-01165-1/a>
Sep 16, 2022
Presenter: Zelin Niu
Paper: van der Wijst, M.G.P., de Vries, D.H., Brugge, H. et al.,
An integrative approach for building personalized gene regulatory networks for precision medicine Genome Med, 2018, 10:96.
doi: https://doi.org/10.1186/s13073-018-0608-4
Sep 9, 2022
Presenter: Xuebing Qiu
Paper: Heyduk, K., Moreno-Villena, J.J., Gilman, I. et al., The genetics of convergent evolution: insights from plant photosynthesis
Nat Rev Genet, 2019, 20:485–493.
doi: https://doi.org/10.1038/s41576-019-0107-5
Aug 19, 2022
Presenter: Hua Zhang
Paper: Wang S, Teng D, Li X, et al., The evolution and diversification of oakleaf butterflies
Cell, 2022, 185(17):3138-3152.
doi: https://doi.org/10.1016/j.cell.2022.06.042
Aug 12, 2022
Presenter: Bingjie Zhu
Paper: Ganna A, Verweij K J H, Nivard M G, et al.,
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Science, 2019, 365(6456).
doi: 10.1126/science.aat7693
Aug 5, 2022
Presenter: Luyan Tian
Paper: Morrill K, Hekman J, Li X, et al., Ancestry-inclusive dog genomics challenges popular breed stereotypes
Science, 2022, 376(6592).
doi: 10.1126/science.abk063
Jul 22, 2022
Presenter: Xueting Hu
Paper: Hu, G., Feng, J., Xiang, X. et al., Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars.
Nature Genetics, 2022, 54:73–83.
doi: https://doi.org/10.1038/s41588-021-00971-3
Jul 22, 2022
Presenter: Jiayu Dong
Paper: Hsieh P, Vollger M R, Dang V, et al., Adaptive archaic introgression of copy number variants and the discovery of previously unknown human genes
Science, 2019, 366(6463).
doi: 10.1126/science.aax208
Jul 8, 2022
Presenter: Xuebo Zhao
Paper: Shen, X., Song, S., Li, C. et al., Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Nature, 2022, 606:725–731.
doi: https://doi.org/10.1038/s41586-022-04823-w
May 13, 2022
Presenter: Xiaohan Yang
Paper: Abell N S, DeGorter M K, Gloudemans M J, et al., Multiple causal variants underlie genetic associations in humans
Science, 2022, 375(6586): 1247-1254.
doi: 10.1126/science.abj5117
May 6, 2022
Presenter: Liping Jiang
Paper: Bradley L, M. D M, Alexandre M, et al., The pan-genome effector-triggered immunity landscape of a host-pathogen interaction
Science, 2020, 367(6479): 763-768.
doi: https://doi.org/10.1038/s41586-022-04549-9
Apr 30, 2022
Presenter: Daxing Xu
Paper: Gardner, E.J., Neville, M.D.C., Samocha, K.E. et al., Reduced reproductive success is associated with selective constraint on human genes.
Nature, 2022, 603: 858–863.
doi: 10.1126/science.aa
Apr 15, 2022
Presenter: Aoyue Bi
Paper: Chen, S. et al., A genome-wide mutational constraint map quantified from variation in 76,156 human genomes.
bioRxiv 2022.03.20.485034
doi: https://doi.org/10.1101/2022.03.20.485034
Apr 08, 2022
Presenter: Yafei Guo
Paper: Sohail M, Vakhrusheva O A, Sul J H, et al., Negative selection in humans and fruit flies involves synergistic epistasis.
Science, 2017, 356(6337): 539-542.
doi: https://www.science.org/doi/10.1126/science.aah5238
Apr 01, 2022
Presenter: Xinyue Song
Paper: Santangelo J S, Ness R W, Cohan B, et al., Global urban environmental change drives adaptation in white clover.
Science, 2022, 375(6586): 1275-1281.
doi: https://www.science.org/doi/10.1126/science.abk0989
Mar 25, 2022
Presenter: Jun Xu
Paper: Vaishnav E D, De Boer C G, Molinet J, et al., The evolution, evolvability and engineering of gene regulatory DNA.
Nature, 2022, 603(7901): 455-463.
doi: https://doi.org/10.1038/s41586-022-04506-6
Mar 18, 2022
Presenter: Lipeng Kang
Paper: Powell D L, García-Olazábal M, Keegan M, et al., Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.
Science, 2020, 368(6492): 731-736.
doi: https://www.science.org/doi/abs/10.1126/science.aba5216
Mar 04, 2022
Presenter: Beirui Niu
Paper:He F, Wang W, Rutter W B, et al., Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat.
Nature Communications, 2022, 13(1): 826.
doi: https://doi.org/10.1038/s41467-022-28453-y
Feb 25, 2022
Presenter: Zelin Niu
Paper: Monroe J G, Srikant T, Carbonell-Bejerano P, et al., Mutation bias reflects natural selection in Arabidopsis thaliana.
Nature, 2022, 602(7895): 101-105.
doi: https://doi.org/10.1038/s41586-021-04269-6
Jan 14, 2022
Presenter: Xuebing Qiu
Paper: Laricchia KM, Lake NJ, Watts NA, et al., Mitochondrial DNA variation across 56,434 individuals in gnomAD.
Genome Res. 2022, 32(3): 569-582.
doi: https://doi.org/10.1101/2021.07.23.453510
2021
Dec 31, 2021
Presenter: Hangyuan Cheng
Paper: Zheng J, Guo N, Wagner A. Selection enhances protein evolvability by increasing mutational robustness and foldability.
Science, 2020, 370(6521).
doi: https://www.science.org/doi/10.1126/science.abb5962
Dec 24, 2021
Presenter: Hua Zhang
Paper: Yonova-Doing E, Calabrese C, Gomez-Duran A, et al., An atlas of mitochondrial DNA genotype–phenotype associations in the UK Biobank.
Nature Genetics, 2021, 53(7): 982-993.
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Dec 10, 2021
Presenter: Xuebo Zhao
Paper: Bergström A, Stringer C, Hajdinjak M, et al., Origins of modern human ancestry.
Nature, 2021, 590(7845): 229-237.
doi: https://doi.org/10.1038/s41586-021-03244-5
Dec 03, 2021
Presenter: Jiayu Dong
Paper: Peter B M. Admixture, Population Structure, and F-Statistics.
Genetics, 2016, 202(4): 1485-1501.
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Nov 26, 2021
Presenter: Liping Jiang
Paper: Avsec Ž, Agarwal V, Visentin D, et al., Effective gene expression prediction from sequence by integrating long-range interactions.
Nature Methods, 2021, 18(10): 1196-1203.
doi: https://doi.org/10.1038/s41592-021-01252-x
Nov 19, 2021
Presenter: Xiaohan Yang
Paper: Bonder M J, Smail C, Gloudemans M J, et al., Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics.
Nature Genetics, 2021, 53(3): 313-321.
doi: https://doi.org/10.1038/s41588-021-00800-7
Nov 12, 2021
Presenter: Song Xu
Paper: Wong A K, Sealfon R S G, Theesfeld C L, et al., Decoding disease: from genomes to networks to phenotypes.
Nature Reviews Genetics, 2021, 22(12): 774-790.
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Nov 05, 2021
Presenter: Daxing Xu
Paper: Frazer J, Notin P, Dias M, et al., Disease variant prediction with deep generative models of evolutionary data.
Nature, 2021, 599(7883): 91-95.
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Oct 28, 2021
Presenter: Aoyue Bi
Paper: Li J T, Wang Q, Huang Yang M D, et al., Parallel subgenome structure and divergent expression evolution of allo-tetraploid common carp and goldfish.
Nature Genetics, 2021, 53(10): 1493-1503.
doi: https://doi.org/10.1038/s41588-021-00933-9
Sep 30,2021
Presenter: Ming Zhang
Paper: Harvey M G, Bravo G A, Claramunt S, et al., The evolution of a tropical biodiversity hotspot.
Science, 2020, 370(6522): 1343-1348.
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Sep 24, 2021
Presenter: Yafei Guo
Paper: Fuller Z L, Mocellin V J L, Morris L A, et al., Population genetics of the coral Acropora millepora: Toward genomic prediction of bleaching.
Science, 2020, 369(6501): 4674.
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Sep 17, 2021
Presenter: Beirui Niu
Paper: Stitzer M C, Anderson S N, Springer N M, et al., The genomic ecosystem of transposable elements in maize.
PLOS Genetics, 2021, 17(10): e1009768.
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Sep 03, 2021
Presenter: Xinyue Song
Paper: Elena K, Benjamin V, N. N B A, et al., Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.
Science, 2020, 368(6498): eaaz5667.
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Aug 27, 2021
Presenter: Xuebing Qiu
Paper: Wang S, Ore M J, Mikkelsen E K, et al., Signatures of mitonuclear coevolution in a warbler species complex.
Nature Communications, 2021, 12(1): 4279.
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Aug 20, 2021
Presenter: Jun Xu
Paper: Sheng X, Guan Y, Ma Z, et al., Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.
Nature Genetics, 2021, 53(9): 1322-1333.
doi: https://doi.org/10.1038/s41588-021-00909-9
Aug 13, 2021
Presenter: Yuqi Bai
Paper: Wang M, Li Z, Zhang Y, et al., An atlas of wheat epigenetic regulatory elements reveals subgenome divergence in the regulation of development and stress responses.
Plant Cell. 2021, 33(4): 865-881.
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Aug 06, 2021
Presenter: Kaibiao Zhang
Paper: Julca I, Ferrari C, Flores-Tornero M, et al., Comparative transcriptomic analysis reveals conserved programmes underpinning organogenesis and reproduction in land plants.
Nature Plants, 2021, 7(8): 1143-1159.
doi: https://doi.org/10.1038/s41477-021-00958-2
Jul 29, 2021
Presenter: Zhengyue Sha
Paper: Corces MR, Granja JM, Shams S, et al., The chromatin accessibility landscape of primary human cancers.
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doi: 10.1126/science.aav1898
Jul 16, 2021
Presenter: Lipeng Kang
Paper: Yang H, Luan Y, Liu T, et al., A map of cis-regulatory elements and 3D genome structures in zebrafish.
Nature, 2020, 588(7837): 337-343.
doi: https://doi.org/10.1038/s41586-020-2962-9
Apr 23, 2021
Presenter: Jijin Zhang
Paper: Jay P, Chouteau M, Whibley A, et al., Mutation load at a mimicry supergene sheds new light on the evolution of inversion polymorphisms.
Nature Genetics, 2021, 53(3): 288-293.
doi: https://doi.org/10.1038/s41588-020-00771-1
Apr 09, 2021
Presenter: Zelin Niu
Paper: Groen S C, Ćalić I, Joly-Lopez Z, et al., The strength and pattern of natural selection on gene expression in rice.
Nature, 2020, 578(7796): 572-576.
doi: https://doi.org/10.1038/s41586-020-1997-2
Apr 02, 2021
Presenter: Zhiliang Zhang
Paper: Peter E, A. A P, Qihui Z, et al., Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Science, 2021, 372(6537): eabf7117.
doi: 10.1126/science.abf7117
Mar 12, 2021
Presenter: Hua Zhang
Paper: Lovell J T, MacQueen A H, Mamidi S, et al., Genomic mechanisms of climate adaptation in polyploid bioenergy switchgrass.
Nature, 2021, 590(7846): 438-444.
doi: https://doi.org/10.1038/s41586-020-03127-1
Mar 05, 2021
Presenter: Xuebo Zhao
Paper: Anders B, Laurent F, Ryan S, et al., Origins and genetic legacy of prehistoric dogs.
Science, 2020, 370(6516): 557-564.
doi: 10.1126/science.aba9572
Jan 22, 2021
Presenter: Liping Jiang
Paper: Vuckovic D, Bao EL, Akbari P, et al., The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Cell. 2020, 182(5): 1214-1231.e11.
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Jan 15, 2021
Presenter: Jiayu Dong
Paper: Skov L, Coll Macià M, Sveinbjörnsson G, et al., The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes.
Nature, 2020, 582(7810): 78-83.
doi: https://doi.org/10.1038/s41586-020-2225-9
Jan 08, 2021
Presenter: Song Xu
Paper: Fachal L, Aschard H, Beesley J, et al., Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Nature Genetics, 2020, 52(1): 56-73.
doi: https://doi.org/10.1038/s41588-019-0537-1